FIELD: chemistry.
SUBSTANCE: invention relates to δ-amino-γ-hydroxy-ω-arylalkanoic acid amides and use thereof as renin inhibitors. δ-amino-γ-hydroxy-ω-arylalkanoic acid amides are a compound of formula
or pharmaceutically acceptable salt thereof, where R1 denotes hydrogen; R2 denotes C1-C4alkoxy(C1-C4)alkoxy; R3 denotes C1-C4alkoxy; R4 denotes hydrogen; X denotes methylene; R5 denotes C1-C4alkyl; R6 denotes amino; R7 denotes C1-C4alkyl; R8 denotes aminocarbonyl(C1-C4)alkyl; R9 denotes C1-C4alkanoyl or a group of formula -COCHR14NR11R12, which can be present in (D)-, (L)- or a racemic (D, L)-configuration; R11 and R12 denote hydrogen; R14 denotes C1-C4alkyl or phenyl(C1-C4)alkyl.
EFFECT: obtaining δ-amino-γ-hydroxy-ω-arylalkanoic acid amides as renin inhibitors.
6 cl, 4 ex
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