TAXANE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT Russian patent published in 1999 - IPC

Abstract RU 2137764 C1

FIELD: organic chemistry, natural compounds, pharmacy. SUBSTANCE: invention describes new derivatives of taxane of the general formula (I) where values R, R¹-R⁸ are given in p. 1 of the invention claim and they can be used as chemotherapeutic agents or their precursors. Invention describes also a method of their synthesis, a pharmaceutical composition based on compounds of the formula (I) and a method of treatment of oncological patients with some cancer species using these new compounds. EFFECT: improved method of synthesis, antitumor activity of compounds. 32 cl, 62 ex

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RU 2 137 764 C1

Authors

Ivao Odzima

Ehtsio Bombardelli

Dates

1999-09-20—Published

1994-03-24—Filed