FIELD: synthesis of biologically active compounds.
SUBSTANCE: invention relates to 7-carboxymethyloxy-3',4',5-trimethoxyflavone monohydrate, which is non-hygroscopic product exhibiting protective activity relative to mucous membrane of gastrointestinal tract, including large intestine, as well as methods for preparation of this compound and pharmaceutical composition based thereon. Compound of invention has such advantages as mucosa-protection activity, handling easiness, and storage ability under humidity conditions because of lack of hygroscopicity, and constant activity allowing preparation of therapeutical composition in any moment when necessary. Preparation procedure is performed under mild conditions owing to elimination of methylation step under autoclave conditions.
EFFECT: enabled mass production of 7-carboxymethyloxy-3',4',5-trimethoxyflavone monohydrate without need in purification such as recrystallization or column chromatography.
15 cl, 5 dwg, 5 tbl, 3 ex
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