DERIVATIVES OF QUINOLONE CARBOXYLIC ACID OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT Russian patent published in 1998 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to new derivatives of quinolone carboxylic acid of the formula (I) , their pharmaceutically acceptable salts and hydrates where X means hydrocarbon group, fluorocarbon group or nitrogen atom; Y means hydrogen atom or methyl group; R¹ means hydrogen atom or C₁-C₅-alkyl group; R² means a group of the formula (a) where A and B mean fluorocarbon group or nitrogen atom at condition that when A is CF then B is N and when A is N then B is CF; R³ means a group of the formula (b) where substitute R⁴ means amino-group with racemate or (S)-enantiomer formation, or a group of the formula (c) where substituents R⁵, R⁶ and R⁷ mean hydrogen atom or C₁-C₃-alkyl group. Derivative of quinolone carboxylic acid of the formula (I) is synthesized by condensation of compound of the formula (II) and compound of the formula HR³ in solvent in the presence of acid acceptor and excess of compound of the formula HR³ that is one of reagents. Solvent is taken from a group involving pyridine, acetonitrile, N,N-dimethylformamide. In compound of the formula (II) and compound of the formula HR³ substituents X, Y, Z, R¹, R² and R³ mean values indicated above. EFFECT: improved method of synthesis. 11 cl, 6 tbl, 29 ex