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RU

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2 304 589

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C1

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IPC

C08F126/10(2006-01-01)

A61K31/79(2006-01-01)

A61K47/32(2006-01-01)

A61P31/00(2006-01-01)

(21) (22)

Application

2006104780/04, 2006-02-15

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Start date

2006-02-15

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Actual filing date

2006-02-15

(45)

Published

2007-08-20

(72)

Inventor

Antonik Lidija MakarovnaKhabibulina Al'Fija GalimullovnaFadeeva Tat'Jana VladimirovnaGrigor'Ev Evgenij GeorgievichKogan Aleksandr Semenovich

(73)

Holder

Irkutskij Institut Khimii Im. A.E. Favorskogo Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)Gosudarstvennoe Uchrezhdenie Nauchnyj Tsentr Rekonstruktivnoj I Vosstanovitel'Noj Khirurgii Vostochno-Sibirskogo Otdelenija Rossijskoj Akademii Meditsinskikh Nauk Nts Rvkh Vsnts So Ramn)

COMPLEX OF POLYVINYLPYRROLIDONE AND 2,3-BIS-(HYDROXYMETHYL)QUINOXALINE 1,4-DI-N-OXIDE (DIOXYDINUM) AND IT USING AS ANTIBACTERIAL COMPLEX WITH PROLONGED EFFECT Russian patent published in 2007 - IPC C08F126/10 A61K31/79 A61K47/32 A61P31/00 

Abstract RU 2304589 C1

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to a complex of polyvinylpyrrolidone and 2,3-bis-(hydroxymethyl)quinoxaline 1,4-di-N-oxide (dioxydinium) of the formula (I) that possesses antibacterial activity with prolonged effect against anaerobic and aerobic infections. Complexes are prepared by interaction of polyvinylpyrrolidone with dioxydinium in the range of weight ratio of reagents = (10:1)-(6:1) (1:0.05-1:0.09 mole) in an aqueous solution at temperature 20-25°C. The structural formula of prepared complexes is confirmed by IK-spectroscopy data. Complexes of polyvinylpyrrolidone with dioxydinium possess antibacterial effect on aerobes and anaerobes and can be used against mixed infections..

EFFECT: valuable medicinal properties of complexes.

3 cl, 1 tbl, 3 ex

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RU 2 304 589 C1

Authors

Antonik Lidija Makarovna

Khabibulina Al'Fija Galimullovna

Fadeeva Tat'Jana Vladimirovna

Grigor'Ev Evgenij Georgievich

Kogan Aleksandr Semenovich

Dates

2007-08-20—Published

2006-02-15—Filed

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