PHARMACEUTICAL COMBINED COMPOSITION FOR LOCAL AND EXTERNAL USE ON BASIS OF BACTERIOLYTIC AND PROTEOLYTIC COMPLEX OF ENZYMES Russian patent published in 2018 - IPC A61K31/00 A61K31/198 A61K35/74 A61K38/43 A61P17/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceutical industry, namely to variants of the pharmaceutical combination composition of antibacterial and necrolytic action for external and topical application. In a first or second embodiment, the composition comprises (in wt %) a base, 0.01–5.0 % lysoamideases, 0.5–6.5 % anesthetic of and 0.1–5.0 % dioxidine or a mixture thereof with 0.01–2.0 % Trilon B; in a third embodiment, the composition comprises (in wt %) a hydrophilic base, 0.01–5.0 % lysoamideases, 0.5–6.5 % anesthetic, 0.01–2.0 % miramistine or decamethoxin and 0.005–4.0 % Trilon B or EDTA; in a fourth embodiment, the composition comprises (in wt %) a hydrophilic base, 0.01–5.0 % lysoamideases, 0.5–6.5 % anesthetic, 0.01–2.5 % ofloxacin or ciprofloxacin, 0.01–2.0 % dioxin or trimethoprim, 0.5–10.5 % xymedon; in a fifth embodiment, the composition comprises (in wt %) a base, 0.01–5.0 % lysoamideases, 0.5–6.5 % anesthetic, 0.2–5.0 % netilmicin or amikacin, 0.1–2.0 % sodium lauryl sulfate, dioxidine, trimethoprim or a mixture thereof.

EFFECT: group of inventions provides an increase in antibacterial and/or antifungal activity.

15 cl, 42 ex, 5 tbl