D-PROLINE-BASED PRODRUGS Russian patent published in 2007 - IPC C07D207/24 C07D498/14 A61K31/407 A61K31/401 A61P25/28

Abstract RU 2305679 C2

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to D-proline derivatives of formula I or IA wherein R¹ and R² are independently lower alcoxy, lower alkenyloxy, hydroxy, -OCH(CH₃)OC(O)-lower alkyl or -OCH₂C(O)N(R³)N(R⁴), with the proviso, that only one from R¹ and R² represent hydroxy; R³ and R⁴ are independently hydrogen, lower alkyl? Lower alkenyl, or cycloalkyl; or R¹ and R² together with carbon atom to which they are attached form linkage group X, wherein X represents -O(CH₂)_nCH=CH(CH₂)_nO- or -O(CH₂)_mO-; n = 1, 2 or 3; m = 4-8.

EFFECT: new prodrugs.

14 cl, 1 tbl, 25(29) ex

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RU 2 305 679 C2

Authors

Khuviler Jerg

Jakob-Retne Roland

Poli Zonija Marija

Dates

2007-09-10—Published

2002-12-06—Filed