FIELD: chemistry.
SUBSTANCE: invention relates to novel AMPA receptor antagonists - 1H-quinazoline-2,4-dione derivatives, selected from the group: N-(6-imidazol-1-yl-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(6-morpholin-4-yl-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(7-nitro-2,4-dioxo-6-pyrrol-1-yl-1,4-dihydro-2H-quinazolin-3-yl)methanesulphonamide; N-(7-nitro-2,4-dioxo-6-[1,2,4]triazol-1-yl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(7-nitro-2,4-dioxo-6-pyrazol-1-yl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(7-nitro-2,4-dioxo-6-pyrrolidin-1-yl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(6-azetidin-1-yl-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(7-nitro-2,4-dioxo-6-[1,2,3]triazol-1-yl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide; N-(6-morpholin-4-yl-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)methanesulphonamide; N-(2,4-dioxo-6-[1,2,4]triazol-4-yl-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)methanesulphonamide; (2,4-dioxo-6-[1,2,4]triazol-4-yl-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)amide ethanesulphonic acid; N-(6-imidazol-1-yl-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)methanesulphonamide; N-(2,4-dioxo-6-thiomorpholin-4-yl-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)methanesulphonamide; N-(6-[1,4]oxazepan-4-yl-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)methanesulphonamide and N-(6-azetidin-1-yl-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulphonamide and physiologically acceptable salts thereof.
EFFECT: compounds can be used in treating such diseases as epilepsy and schizophrenia.
9 cl, 106 ex
| Title | Year | Author | Number |
|---|---|---|---|
| TRICYCLIC DICARBONYL DERIVATIVES AND DRUG BASED ON SAID | 1995 |
|
RU2145606C1 |
| DERIVATIVES OF BENZODIAZEPINE AND MEDICINAL AGENT COMPRISING THEREOF | 2000 |
|
RU2259360C2 |
| DERIVATIVES OF DIHYDROBENZO[b][1,4]DIAZEPINE-2-ONE AS I mGluR2 ANTAGONISTS | 2002 |
|
RU2270197C2 |
| DERIVATIVES OF DIHYDROBENZO[b][1,4]DIAZEPINE-2-ONE AS ANTAGONISTS OF MGLUR2 II | 2002 |
|
RU2263112C2 |
| QUINOXALINE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2135484C1 |
| DERIVATIVES OF AMINOPHOSPHONIC AND AMINOPHOSPHINIC ACIDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 1997 |
|
RU2181362C2 |
| NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND COSMETICS | 2015 |
|
RU2712971C2 |
| AMINOMETHYL QUINOLONES USEFUL IFOR TREATMENT OF JNK-MEDIATED DISORDER | 2012 |
|
RU2629111C2 |
| IMIDAZOLIDINE-2,4-DIONE DRIVATIVES AND USING THEM AS ANTI-CANCER DRUG | 2010 |
|
RU2497812C2 |
| MODULATORS OF ATP-BINDING TRANSPORTERS | 2010 |
|
RU2552353C2 |
