4-AMINO-5-PHENYL-7-CYCLOBUTYLPYRROLO[2,3-D]PYRIMIDINE DERIVATIVES Russian patent published in 2007 - IPC C07D487/04 A61K31/519 A61P35/00 

Abstract RU 2305682 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to 4-amino-5-phenyl-7-cyclobutylpyrrolo[2,3-d]pyrimidine derivatives of general formula I wherein meanings of R1, R2, R4, and X are as described in the disclosure, and salts thereof. Said derivatives are capable to inhibit IGR-IR tyrosin kinase activity and are useful in production of pharmaceutical composition for treatment of proliferative decisions. Pharmaceutical composition based on abovementioned derivatives and method for production thereof also are disclosed.

EFFECT: new derivatives for treatment of proliferative decisions.

9 cl, 134 ex

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RU 2 305 682 C2

Authors

Kapraro Khans-Georg

Fjure Paskal'

Garsija-Ehcheverrija Karlos

Manli Pol Uill'Jam

Dates

2007-09-10Published

2002-05-13Filed