JAK INHIBITORS Russian patent published in 2015 - IPC C07D487/04 A61K31/4985 A61P29/00 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula I wherein R means C_1-6alkyl, C_1-6halogenalkyl, hydroxy-C_1-6alkyl, hydroxygroup or halogen; m, n is equal to 0 or 1; Z¹ means CH or NH; Z² means CH or N; Z³ means CR¹, N or NR²; R¹ means H, C_1-6alkyl, C_3-7cycloalkyl, cyanogroup, cyano-C_1-6alkyl or halogen; R² means H or C_1-6alkyl; X means CH, CR' or N; X' means CH, CR' or N; r is equal to 1; Y means CH or CR'; R' means R'^a or R'^b; R'^a means a halogen or cyanogroup; R'^b means C_1-6alkyl, heterocycloalkyl specified in piperazinyl, morpholinyl, piperidinyl, thiomorpholinyl, azetidinyl, pyrrolidinyl, OR", SR", S(=O)₂R" or NR"R", optionally substituted by one or more R'^c; R'^c means a hydroxygroup, oxogroup, cyanogroup, C_1-6alkyl, pyridinyl, carboxy-C_1-6alkyl, aminocarbonyl-C_1-6alkylaminogroup, C_1-6alkylaminogroup, C_1-6dialkylaminogroup or C_1-6alkoxygroup; R" means H, C_1-6alkyl, hydroxy-C_1-6alkyl, piperidinyl, C_3-7cycloalkyl or pyridinyl; Q means S(=O)₂Q¹, C(=O)Q², C(=O)OQ³ or Q⁴; Q¹ means C_1-6alkyl, C_3-7cycloalkyl-C_1-6alkyl, C_1-6alkylaminogroup or C_1-6dialkylaminogroup optionally substituted by one or more Q¹'; each Q¹' independently means C_1-6alkyl or cyanogroup; Q² means C_1-6alkyl optionally substituted by one or more Q²'; each Q²' independently means a cyanogroup; Q³ means C_1-6alkyl; Q⁴ means C_1-6alkyl, oxetanyl optionally substituted by one or more Q⁴'; each Q⁴' independently means a halogen, cyanogroup, cyano-C_1-6alkyl; p is equal to 0, 1 or 2; q is equal to 1 or 2; each means a single bond or a double bond; provided one of Z¹ and Z², and Z³ and Z³ bonds are double and single.

EFFECT: compounds of formula I as JAK inhibitors.

23 cl, 2 tbl, 121 ex