1,2,3,4,5,6,10,11,12,13,14,15,15a,15b-TETRADECAHYDRO-DICYCLONONE[b,d]THIOPHENE SYNTHESIS METHOD Russian patent published in 2010 - IPC C07D333/78 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a method for synthesis of 1,2,3,4,5,6,10,11,12,13,14,15,15a,15b-tetradecahydro-dicyclonone[b,d]thiophene of general formula (1): characterised by that cyclonone-1,2-diene is reacted with ethylmagnesium bromide (EtMgBr/ether) in the presence of Mg (powder) and a titanocene dichloride (Cp₂TiCl₂) catalyst taken in molar ratio cyclonone-1,2-diene : EtMgBr : Mg : Cp₂TiCl₂ = 20:(22-26):20:(1.0-1.4), preferably 20:24:20:1.2, in an argon atmosphere at room temperature (20-22°C) and atmospheric pressure for 6-8 hours in diethyl ether, with subsequent addition of an amount of elementary sulphur S₈ which is equimolar to k EtMgBr, benzole as a solvent and heating the reaction mass for 5 hours at temperature of approximately 40°C.

EFFECT: design of a method of obtaining a new compound 1,2,3,4,5,6,10,11,12,13,14,15,15a,15b- tetradecahydro-dicyclonone[b,d]thiophene which can be used in fine organic synthesis, as well as for synthesis of biologically active heterocyclic compounds.

1 cl, 1 tbl, 1 ex