FIELD: organic chemistry.
SUBSTANCE: group of inventions includes compounds of formulas II, IV, as well as individual compounds specified in the claim, a pharmaceutical composition based on them and use thereof. In formula II, X and Y are N and Z is CR; R is H; Ra is selected from the group consisting of H, substituted or unsubstituted C1-C6 alkyl group; U is a chemical bond or -NH-; and when U is a chemical bond, then Rc is pyrrolidine; Rc is selected from a group consisting of a substituted or unsubstituted C1-C6 alkyl group, a substituted or unsubstituted C3-C8 carbocyclic ring, substituted or unsubstituted 3–8-membered heterocyclic ring containing 1–2 heteroatoms selected from oxygen, sulfur and nitrogen atoms; Re is selected from a group consisting of -NHR; wherein R is selected from a group consisting of H; W is substituted or unsubstituted phenyl, and a substituted or unsubstituted 5–6 membered heteroaromatic ring containing 1–2 heteroatoms selected from the group consisting of sulfur and nitrogen atoms; in addition to the common substituent, the W group is further substituted with at least one group with the -MA structure, where M is selected from the group consisting of a chemical bond or -CHR-; other substitutes are as specified in the patent claim. In formula IV, substitutes are as specified in the claim.
EFFECT: pyridino[3,4-b]pyrazine derivatives used to treat diseases associated with abnormal gene levels or abnormal expression of kinases selected from a group consisting of FLT3, ALK and AXL.
16 cl, 2 tbl, 360 ex
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