[(AMMONIA)METHYLCARBONYLOXYPOLY(ALKLYLENEOXY)]-PROPANE CHLORIDES HAVING BACTERICIDAL ACTIVITY AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2007 - IPC C08G65/333 C08G65/32 A61K31/765 

Abstract RU 2308467 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to compounds of general formula , wherein: when X=Y=Z=R1R2R3N+, R1=R2=H R3=aliphatic C17-C20-hydrocarbon radical, a+c+e = 49, b+d+f = 9, n = 3; when X=Y=Z=R1R2R3N+, R1=R2=H R3=aliphatic C17-C20-hydrocarbon radical, a+c+e = 55, b+d+f = 10, n = 3; when X=Y=Z=R1R2R3N+, R1=R2=H R3= C16H33, a+c+e = 49, b+d+f = 9, n = 3; when X=Y=Z=R1R2R3N+, R1=R2=H R3=C16H33, a+c+e = 55, b+d+f = 10, n = 3; when X=Y=Z=R1R2R3N+, R1=R2=H, R3=C16H33, a+c+e = 66, b+d+f = 15, n = 3; when X=Y=Z=R1R2R3N+, R1=R2=H R3=C16H33, a+c+e = 76, b+d+f = 18, n = 3; when X=Y=Z=R1R2R3N+, R1=R2=H R3=C16H33, a+c+e = 49, b+d+f = 9, n = 1; when X=Y=Z=R1R2R3N+, R1=R2=H R3=C16H33, a+c+e = 55, b+d+f = 10, n = 1; when X=Y=Z=R1R2R3N+, R1=R2=H R3=C16H33, a+c+e = 49, b+d+f = 0, n = 1; when X=Y=Z=R1R2R3N+, R1=R2=H R3=C16H33, a+c+e = 55, b+d+f = 0, n = 1. Also disclosed is method for production of abovementioned compounds by interaction of 1,2,3-tris[hydroxypoly(alkyleneoxy)]-propanes with monochloroacetic acid in presence of acetic catalyst in medium of boiling organic solvent with azeotropic removing of formed water followed by treatment at heating of obtained product in polar solvent medium with amine compounds of formula R1R2R3N, wherein R1=R2=H; R3=C16H33, aliphatic C17-C20-hydrocarbon radical, in molar ratio of hydroxy propane derivative: monochloroacetic acid:amine compound = 1:3.0-3.2:3.0-3.2, respectively.

EFFECT: new compounds with bactericidal activity.

7 cl, 1 tbl, 10 ex

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Authors

Fakhretdinov Pavel Sagitovich

Ugrjumova Valentina Stepanovna

Nuriev Il'Dar Mukhamatnurovich

Ravilov Abdulkhamit Zaripovich

Ivanov Arkadij Vasil'Evich

Romanov Gennadij Vasil'Evich

Savrilov Marsel' Robinzonovich

Jusupova Galija Rasykhovna

Kamalov Bulat Vagizovich

Chulkov Aleksej Konstantinovich

Dates

2007-10-20Published

2005-07-06Filed