SEPARATION OF 3-AMINOALKYLNITRYLES Russian patent published in 2007 - IPC C07C253/32 C07C255/24 C07B57/00

Abstract RU 2309145 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to chiral N-acetyl-alpha-amino acid salts and optically active beta-aminoalkylnitriles, in particular compound of formula IIa , wherein R is methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl; Q is N-acetyl-alpha-amino acid. Also invention relates to method for conversion of racemic 3-amino-(C₃-C₇)-alkylnitrile of formula I to corresponding (R) isomer of formula IIf. Claimed method includes interaction of racemic 3-amino-(C₃-C₇)-alkylnitrile of formula I with N-acetyl-alpha-amino acid of formula Q in solvent. Also disclosed is method for conversion of R or S 3-amino-(C₃-C₇)-alkylnitrile to racemic 3-amino-(C₃-C₇)-alkylnitrile by interaction of R or S 3-amino-(C₃-C₇)-alkylnitrile with aqueous ammonia at 30-200°C. Composition useful as structure units in synthesis of optically active beta-amino acids, enriched with compound of formula IIa and compound of formula I, wherein Q is N-acetyl-alpha-amino acid; and R is as defined above also are disclosed.

EFFECT: new method for separation of 3-aminoalkylnitryles.

2 dwg, 8 ex

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RU 2 309 145 C1

Authors

Kolberg Khuan Karlos

Zambelli Frants Samuehla

Motterle Rikkardo

Stivanello Mariano

Dates

2007-10-27—Published

2004-10-18—Filed