SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PREPARING (VARIANTS) AND USING AS AGENTS AGAINST OBESITY AND HYPERHOLESTEROLEMIA Russian patent published in 2006 - IPC C07D265/36 C07D279/16 C07D413/12 C07D417/12 A61K31/538 A61K31/5415 A61P3/06 A61P3/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to substituted bicyclic heterocyclic compounds of the formula (I): their tautomeric forms, stereoisomers, polymorphous forms, pharmaceutically acceptable salts and pharmaceutically acceptable solvates wherein groups R¹, R², R³ and R⁴, and groups R⁵ and R⁶ when they are bound with carbon atom they represent hydrogen, halogen atom, hydroxy-group, alkyl, alkoxy-group; R⁵ and R⁶ as a single group or both can represent also an oxo-group when they are bound with carbon atom; when R⁵ and R⁶ are bound with nitrogen atom then they represent hydrogen atom, hydroxy-group or such unsubstituted groups as alkyl, alkoxy-group, aralkyl. X means oxygen or sulfur atom; Ar means phenylene, naphthylene or benzofuryl. Proposed compounds can be used against obesity and hypercholesterolemia. Also, the invention describes methods for preparing compounds, pharmaceutical compositions, method for treatment and using compounds proposed.

EFFECT: valuable medicinal properties of compounds and compositions.

52 cl, 77 ex