METHOD OF PRODUCING CARBOXY-SUBSTITUTED GLYCOPEPTIDES OF GLYCYRRHIZIC ACID Russian patent published in 2016 - IPC C07J53/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing glycyrrhizic acid derivatives of formula I: , which are suitable for use in chemical industry. In the disclosed method, compounds of general formula I are obtained by treating glycyrrhizic acid (GA) with N-hydroxybenzotriaozole (HOBt), carbodiimide and an amine component (AC) with molar ratio of reactants GA/HOBt/AC/carbodiimide, equal to 1/3.5-4.0/3.5-4.0/3.5-4.0 mmol at room temperature in N,N′-dimethyl formamide in the presence of N-ethyl morpholine, wherein the carbodiimide used is 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride, the amine component is hydrochlorides of amino acid esters of formula R₁NH₂·HCl, where R₁=C₆H₅CH₂CH(COOCH₃)-, HOC₆H₄CH₂CH(COOCH₃)-, (CH₃)₂CHCH₂CH(COOCH₃)-, CH₃CH₂CH(CH₃)CH(COOCH₃)-, (CH₃)₂CHCH(COOCH₃)-, CH₃SCH₂CH₂CH(COOCH₃)-, C₆H₅CH₂SCH₂CH(COOC(CH₃)₃-, where the process takes place in a single step for 10-12 hours.

EFFECT: novel efficient method of producing valuable compounds, which simplifies production with high output.

2 cl, 1 ex