FIELD: medicine, pharmacy.
SUBSTANCE: invention proposes using the known soporific and modulator of GABA activity zopiclone as a drug showing multifactor neuroprotective effect on ischemia, hypoxia with hypercapnia and convulsions in acute period of cranial trauma. Invention provides prophylaxis of secondary complications caused by cranial trauma and normalization of nervous-psychic status. It has shown that in first three days of post-traumatic period zopiclone increased resistance of brain in trauma to ischemia, hypoxia, hypercapnia and convulsions by 24.9-42.6% as compared with effect of nimodipine or antioxidant sodium hydroxybutyrate.
EFFECT: enhanced and valuable medicinal properties of drug.
4 tbl
| Title | Year | Author | Number |
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| MEDICINAL AGENT SHOWING MULTIFACTOR NEUROPROTECTIVE AND NOOTROPIC EFFECT IN CRANIAL TRAUMA | 2005 |
|
RU2318501C2 |
| MEDICATION PRODUCING ANTI-ISCHEMIC, ANTIHYPOXIC AND ANTIAMNESTIC ACTION IN ACUTE PERIODE OF CRANIOCEREBRAL TRAUMA | 2009 |
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RU2424802C2 |
| MEDICATION, PROVIDING NEURO-PROTECTIVE ACTION IN ACUTE PERIOD OF CRANIOCEREBRAL INJURY | 2009 |
|
RU2414901C2 |
| ANTICONVULSANT AND ANTIHYPOXIC AGENT | 2008 |
|
RU2393857C2 |
| METHOD FOR TREATMENT OF CEREBROVASCULAR BRAIN DISORDERS (OPTIONS) | 2017 |
|
RU2659674C1 |
| APPLICATION OF BETA-HYDROXYBUTYRATE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR PREPARATION OF MEDICATION WHICH POSSESSES CYTOPROTECTIVE ACTIVITY, INCLUDING NEUROPROTECTIVE, CARDIOPROTECTIVE, ANTI-ISCHEMIC, ANTI-HYPOXIC, ANTI-STRESS, ACTOPROTECTIVE AND ADAPTOGENIC ACTIVITY, MEDICATION AND METHOD OF PREVENTION, RELIEF AND TREATMENT BY MEANS OF SAID MEDICATION | 2009 |
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RU2426535C2 |
| METHOD OF PREPARING THE BIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX NORMALIZING BRAIN FUNCTIONS FROM ANIMAL RAW, PHARMACOLOGICAL COMPOSITION AND ITS USING | 1996 |
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RU2104702C1 |
| DRUG POSSESSING ACTOPROTECTIVE, ANTIHYPOXIC, NEUROPROTECTIVE, ANTIAMNESTIC AND THERMOPROTECTIVE ACTIVITY | 2011 |
|
RU2460529C1 |
| AGENT FOR PREVENTION AND TREATMENT OF ACUTE AND CHRONIC CEREBROVASCULAR DISEASE, USE AND METHOD OF TREATING | 2011 |
|
RU2468813C1 |
| NEURORABILITATION AGENT BASED ON SODIUM 6-OXO-1-PHENYL-2-(PHENYLAMINO)-1,6-DIHYDROPYRIMIDINE-4-OLATE | 2018 |
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RU2675694C1 |
