FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, protein engineering and medicine. Described is a method of producing antigen-specific cytotoxic cells with anticancer activity against breast cancer cells. Present invention provides generation in vitro of antigen-specific clones of T-cells with activity of CD8 + T-cells and T-helpers type 1, required for formation of effective anticancer response against breast cancer cells.
EFFECT: invention can be used in medicine.
1 cl, 2 dwg, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR STIMULATING CYTOTOXIC IMMUNE RESPONSE TO TUMOUR CELLS OF MAMMARY ADENOCARCINOMA EXPRESSING SPECIFIC ANTIGENS, WITH USE OF DENDRITE CELLS TRANSFECTED BY POLYEPITOPE DNA CONSTRUCT | 2012 |
|
RU2520091C2 |
| METHOD FOR PRODUCTION OF IN VITRO POPULATIONS OF ACTIVATED ANTIGENSPECIFIC ANTITUMOR-TUMOR CYTOTOXIC T-LYMPHOCYTES SPECIFIC TO TUMOR-ASSOCIATED ANTIGEN EPITOPES | 2016 |
|
RU2619186C1 |
| POLYEPITOPE ANTI-TUMOUR VACCINE STRUCTURE CONTAINING EPITOPES OF TUMOR-ASSOCIATED ANTIGENS, PHARMACEUTICAL COMPOSITION AND ITS APPLICATION FOR STIMULATING SPECIFIC ANTI-TUMOR IMMUNE RESPONSE | 2016 |
|
RU2684235C2 |
| POLYEPITOPE IMMUNOGENIC POLYPEPTIDES AND METHODS OF APPLICATION THEREOF | 2013 |
|
RU2598265C2 |
| RECOMBINANT PLASMID DNA pCI-UB-POLYEPI CONTAINING EPITOPES OF TUMOUR-ASSOCIATED ANTIGENS FOR COLORECTAL CANCER AND METHOD OF ITS APPLICATION FOR STIMULATION OF SPECIFIC ANTITUMOUR IMMUNE RESPONSE AGAINST COLORECTAL CANCER CELLS | 2012 |
|
RU2507265C2 |
| PREVENTIVE OR THERAPEUTIC POLYEPITOPIC ANTI-TUBERCULOSIS VACCINE CONSTRUCTION PROVIDING INDUCTION OF CELLULAR IMMUNE RESPONSE OF CD4+ OR CD8+ T-LYMPHOCYTES | 2011 |
|
RU2539035C2 |
| METHOD FOR OBTAINING OF MATURE ANTIGEN-ACTIVATED DENDRITIC CELLS WITH TRANSFECTION OF TUMOUR CELLS RNA OF BREAST CANCER | 2016 |
|
RU2631792C2 |
| METHOD OF GENERATING ANTIGEN-SPECIFIC CYTOTOXIC CELLS WITH ANTITUMOUR ACTIVITY IN BREAST CANCER | 2013 |
|
RU2521506C1 |
| IMMUNOTHERAPY OF BREAST CANCER USING ANTIGEN-ACTIVATED DENDRITIC CELLS | 2016 |
|
RU2645464C1 |
| METHOD OF INDUCING CYTOTOXIC ANTI-TUMOUR IMMUNE RESPONSE in vitro WITH USING DENDRITIC CELLS, TRANSFECTED BY RNA TUMOUR CELLS, TO NON-SMALL CELL LUNG CANCER | 2015 |
|
RU2578008C1 |
