AMINOALKYLPYRIDINE DERIVATIVES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF Russian patent published in 2007 - IPC C07D213/30 C07D213/38 A61P3/06 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel derivatives of aminoalkylpyridines of the general formula (I): wherein n means a whole number from 1 to 4; R₁ represents hydrogen atom, hydroxyl group or lower (C₁-C₆)-alkoxy-group; R₂ represents hydrogen atom or lower (C₁-C₆)-alkyl group with linear or branched chain; X represents hydrogen atom, fluorine atom, chlorine atom, bromine atom, hydroxyl group, trifluoromethyl group, 3,4-di-Cl, 2,4-di-Cl or lower (C₁-C₆)-alkoxy-group, or salts of these compounds as products of adding physiologically acceptable acid. Also, invention relates to a pharmaceutical composition based on these compounds inhibiting biosynthesis of cholesterol. Also, invention considers using abovementioned compounds in preparing pharmaceutical composition and to a method for synthesis of compounds of the formula (I). Invention provides synthesis of novel compounds possessing valuable biological properties and preparing pharmaceutical composition based on thereof.

EFFECT: improved preparing method, valuable medicinal properties of compounds and pharmaceutical composition.

10 cl, 12 dwg, 5 ex