3R,5S-(+)-7-[4- (4-FLUOROPHENYL) -2,6-DIISOPROPYL-5- METHOXYMETHYL- PYRID-3-YL] -3,5- DIHYDROXYHEPTENOIC ACID IN ERYTHRO-(E)-CONFIGURATION IN THE FORM OF PHYSIOLOGICALLY TOLERATED METAL SALT AS AN INHIBITOR OF CHOLESTEROL BIOSYNTHESIS Russian patent published in 1995 - IPC

Abstract RU 2026290 C1

FIELD: organic chemistry. SUBSTANCE: product: 3R,5S-(+)-7-[4- (4-fluorophenyl) -2,6-diisopropyl-5- methoxymethyl- pyrid-3-yl] -3,5- dihydroxyheptenoic acid, empirical formula is C26H34NO5F, yield is 48%. Reagent 1: methyl ether of erythro-(E)-7- [4-(4-fluorophenyl) -2,6-diisopropyl-5- methoxymethyl- pyrid-3-yl] -3,5-dioxyhept -6-enoic acid. Reagent 2: R-(+)-phenylethylamine or S-(+)-phenylglycinol. Reaction conditions: at heating in the solvent medium following by hydrolysis in acid medium. EFFECT: improved method of synthesis.

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RU 2 026 290 C1

Authors

Rol'F Angerbauer[De]

Peter Faj[De]

Val'Ter Khjubsh[De]

Tomas Filipps[De]

Khil'Mar Bishoff[De]

Diter Pettsinna[De]

Del'F Shmidt[De]

Gjunter Tomas[De]

Dates

1995-01-09Published

1991-12-13Filed