FIELD: organic chemistry. SUBSTANCE: product: 3R,5S-(+)-7-[4- (4-fluorophenyl) -2,6-diisopropyl-5- methoxymethyl- pyrid-3-yl] -3,5- dihydroxyheptenoic acid, empirical formula is C26H34NO5F, yield is 48%. Reagent 1: methyl ether of erythro-(E)-7- [4-(4-fluorophenyl) -2,6-diisopropyl-5- methoxymethyl- pyrid-3-yl] -3,5-dioxyhept -6-enoic acid. Reagent 2: R-(+)-phenylethylamine or S-(+)-phenylglycinol. Reaction conditions: at heating in the solvent medium following by hydrolysis in acid medium. EFFECT: improved method of synthesis.
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PREPARING INHIBITORS OF HMG-COA-REDUCTASE | 2003 |
|
RU2299196C2 |
METHOD OF PRODUCTION OF MEVALONIC ACID DERIVATIVES INHIBITING HMG-COA REDUCTASE | 2003 |
|
RU2335500C2 |
DERIVATIVES OF PYRIDOBENZOXADIAZINE CARBOXYLIC ACID, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS, THEIR PHARMACEUTICALLY USED HYDRATES AND SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY ON THEREOF | 1995 |
|
RU2138504C1 |
DERIVATIVES OF 7-ISOINDOLINYLQUINOLONE AND 7-ISOINDOLINYLNAPHTHYRIDONE | 1993 |
|
RU2111964C1 |
DERIVATIVES OF CYCLOALKANOPYRIDINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS | 1997 |
|
RU2194698C2 |
DERIVATIVES OF PYRIDOBENZOXADIAZINE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS, THEIR HYDRATES AND SALTS | 1994 |
|
RU2131430C1 |
QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2105770C1 |
PIPERIDYLMETHYL-SUBSTITUTED CHROMAN DERIVATIVES AND THEIR SALTS WITH INORGANIC ACIDS | 1992 |
|
RU2102392C1 |
1-ALKYL-3,5-DIALYL-1,4-DIHYDROPYRIDINE DERIVATIVES AS MIXTURE OF ISOMERS THEREOF | 1995 |
|
RU2158259C2 |
COMBINATION CONTAINING A COMPOUND OF ANGIOTENSIN II-ANTAGONISTIC ACTIVITY | 1997 |
|
RU2188013C2 |
Authors
Dates
1995-01-09—Published
1991-12-13—Filed