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(19)

(11)

2 404 972

(13)

(51)

IPC

C07D231/54(2006-01-01)

C07D231/56(2006-01-01)

C07D401/06(2006-01-01)

C07D403/06(2006-01-01)

C07D491/20(2006-01-01)

A61K31/454(2006-01-01)

A61K31/4725(2006-01-01)

A61K31/496(2006-01-01)

A61K31/5377(2006-01-01)

A61K31/55(2006-01-01)

A61K31/438(2006-01-01)

A61K31/4178(2006-01-01)

A61K31/541(2006-01-01)

A61P29/00(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2007111119/04, 2005-08-29

(24)

Start date

2005-08-29

(22)

Actual filing date

2005-08-29

(45)

Published

2010-11-27

(72)

Inventor

Korbera Arkhona KhordiKuberes-Altisent Marija RosaKholents JorgMartines-Ol'Mo Daniehl'Van'O-Domenech David

(73)

Holder

Laborator'Os Del' Dr.Ehsteve, S.A.

SIGMA-RECEPTOR INHIBITORS Russian patent published in 2010 - IPC C07D231/54 C07D231/56 C07D401/06 C07D403/06 C07D491/20 A61K31/454 A61K31/4725 A61K31/496 A61K31/5377 A61K31/55 A61K31/438 A61K31/4178 A61K31/541 A61P29/00 A61P25/00

Abstract RU 2404972 C2

FIELD: medicine.

SUBSTANCE: invention refers to new compounds with pharmacological activity to sigma-receptor, and more specifically to pyrazole derivatives of formula (I) in which radicals and symbols have the values defined in cl. 1 of the patent claim; to a method for preparing such compounds; to a pharmaceutical composition containing them and to their application for manufacturing a medicinal agent for treatment and prevention of a sigma-receptor mediated disease or a condition, particularly for treatment of psychotic illness, such as depression, anxiety or schizophrenia, and neuropathic or inflammatory pain, including allodynia and/or hyperalgesia.

EFFECT: improved clinical effectiveness.

11 cl, 2 dwg, 1 tbl, 112 ex

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RU 2 404 972 C2

Authors

Korbera Arkhona Khordi

Kuberes-Altisent Marija Rosa

Kholents Jorg

Martines-Ol'Mo Daniehl'

Van'O-Domenech David

Dates

2010-11-27—Published

2005-08-29—Filed