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(19)

(11)

2 582 338

(13)

(51)

IPC

C07D231/12(2006-01-01)

C07D413/06(2006-01-01)

C07D403/12(2006-01-01)

C07D413/12(2006-01-01)

C07D401/04(2006-01-01)

A61K31/4155(2006-01-01)

A61K31/454(2006-01-01)

A61K31/496(2006-01-01)

A61K31/5377(2006-01-01)

A61P25/00(2006-01-01)

A61P3/00(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2012156925/04, 2011-05-26

(24)

Start date

2011-05-26

(22)

Actual filing date

2011-05-26

(45)

Published

2016-04-27

(72)

Inventor

Garsija Lopes MonikaTorrens Khover AntoniDias Fernandes Khose LuisKaamano Moure Ana Marija

(73)

Holder

Laboratoros Del Dr. Esteve, S.A.

PYRAZOLE COMPOUNDS AS SIGMA RECEPTOR INHIBITORS Russian patent published in 2016 - IPC C07D231/12 C07D413/06 C07D403/12 C07D413/12 C07D401/04 A61K31/4155 A61K31/454 A61K31/496 A61K31/5377 A61P25/00 A61P3/00 A61P29/00

Abstract RU 2582338 C2

FIELD: medicine.

SUBSTANCE: invention refers to compounds of general formula (1)

shown below, or their pharmaceutically acceptable salts having pharmacological activity towards sigma receptor, to methods for producing these compounds and to pharmaceutical compositions containing them, and to using them for treating and/or preventing sigma receptor-related diseases. In the compounds of formula (I), R¹ represents phenyl substituted by halogen atoms; naphthyl; C_5-6 cycloalkyl; or quinolyl; R² and R³ are independently specified in H and C_1-6 alkyl group; R⁴ and R⁵ together with the nitrogen atom to which they are attached, form a substituted or unsubstituted 5-6-merous heterocyclyl group with one or two heteroatoms specified in O or N, wherein the substitute is specified in C_1-6alkyl and C_1-6alkanoyl; X represents an oxygen atom or a CH₂ group; m is specified in 1, 2, 3 and 4; and n is specified in 1, 2, 3 and 4.

EFFECT: higher efficacy.

13 cl, 2 tbl, 50 ex

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RU 2 582 338 C2

Authors

Garsija Lopes Monika

Torrens Khover Antoni

Dias Fernandes Khose Luis

Kaamano Moure Ana Marija

Dates

2016-04-27—Published

2011-05-26—Filed