METHOD FOR INITIAL ISOLATION OF INFLUENZA VIRUS A STRAIN, STRAIN VIRUS A/DUCK/NOVOSIBIRSK/56/05 H5N1 FOR PREPARATION FOR DIAGNOSIS, PROPHYLAXIS AND THERAPEUTICAL AGENTS, AND FOR EVALUATION OF ANTIVIRAL ACTIVITY OF VARIOUS COMPOUNDS Russian patent published in 2007 - IPC C12N7/00 

Abstract RU 2309983 C2

FIELD: medical virology.

SUBSTANCE: initial isolation of influenza virus A/H5N1 strain is carried out by contamination of cell culture of porcine embryo kidney. Contaminated culture is incubated in supporting medium 199 with penicillin and streptomycin addition in presence of medium TPCK treated tripsin. Disclosed is strain A/duck/Novosibirsk/56/05 H5N1 isolated by abovementioned method. Strain is capable of inducing virus neutralizing protective antibodies and is useful in preparation of test-systems and other diagnosis preparations.

EFFECT: strain of high antigen activity.

4 cl, 1 tbl, 4 ex

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RU 2 309 983 C2

Authors

L'Vov Dmitrij Konstantinovich

Shchelkanov Mikhail Jur'Evich

Derjabin Petr Grigor'Evich

Grebennikova Tat'Jana Vladimirovna

Prilipov Aleksej Gennad'Evich

Nepoklonov Evgenij Anatol'Evich

Vlasov Nikolaj Anatol'Evich

Aliper Taras Ivanovich

Zaberezhnyj Aleksej Dmitrievich

Kireev Dmitrij Evgen'Evich

Dates

2007-11-10Published

2005-11-25Filed