FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel analogues of 2',5'-oligoadenylate represented by the general formula (1): 
or their pharmacologically acceptable salts possessing antiviral and antitumor activity, to a pharmaceutical composition based on thereof, and their using as a medicinal agent in preparing a medicinal agent. In the formula (1) E1 represents group of the formula (K2): 
; E2 represents group of the formula (K1): 
; E3 represents group of the formula (K2) or (K3): 
, and E4 represents group of the formula (K1), (K2), (K3) or (K4): 
. Values of substitutes R1 - R8, m, n, A, B and D are given in the invention claim.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
10 cl, 4 tbl, 1 graph, 90 ex
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