CYCLIC INHIBITORS OF PROTEIN-TYROSINE KINASES Russian patent published in 2005 - IPC C07D417/14 A61K31/427 A61P35/00 A61P37/00 

Abstract RU 2260592 C9

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide of the formula: and to its pharmaceutically acceptable salts. Also, invention describes a pharmaceutical composition inhibiting activity of protein-tyrosine kinases and comprising the indicated compound, a method for treatment of disorders associated with protein-tyrosine kinases, such as an immune disorder, and oncology disease, and a method for cancer treatment.

EFFECT: valuable biochemical and medicinal properties of compounds and composition.

5 cl, 2 tbl, 581 ex

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RU 2 260 592 C9

Authors

Das Dzhagabandkhu

Padmanabkha Ramesh

Chen Ping

Norris Derek Dzh.

Dovejko Artur M. P.

Behrrish Dzhoehl S.

Vitjak Dzhon

Dates

2005-09-20Published

2000-04-12Filed