VECTORS FOR DELIVERY OF MOLECULES TO CD11b-EXPRESSING CELLS Russian patent published in 2007 - IPC C12N9/00 C07K14/235 C07K19/00 A61K38/43 A61P43/00 

FIELD: molecular biology, biochemistry, microbiology.

SUBSTANCE: invention relates to using adenylcyclase toxin from microorganisms of genus Bordetella in producing protein vectors used in targeting a molecule to cell expressing CD11b. This molecule is chosen from the following group comprising peptides, glycopeptides, lipopeptides, polysaccharides, oligosaccharides, nucleic acids, lipids and chemicals. Molecule shows antigenic properties, it is targeted and translocated to cytosol in cells expressing CD11b. Also, invention relates to using immunogenic composition based on adenylcyclase from microorganism of genus Bordetella as a vaccine for preparing the immunotherapeutic composition. Invention describes a protein vector comprising adenylcyclase from microorganism of genus Bordatella for targeting to cells expressing CD11b, in particular, to cytosol of these cells directly. Invention provides agents that can target molecules in vivo specifically to definite populations of pAPC for providing possibility for stimulation of the immune system.

EFFECT: valuable biological properties of vectors.

56 cl, 60 dwg, 1 tbl, 1 ex