FIELD: biochemistry; medicine.
SUBSTANCE: disclosed is a composition for immunotherapeutic treatment or prophylaxis of a condition which is a consequence of infection with HPV16 and/or HPV18, comprising a pharmaceutically acceptable base or composition and an effective amount of at least one vector from a protein CyaA Bordatella pertussis or a fragment thereof, carrying polypeptides containing epitope HPV16 E7Δ30-42 and epitope HPV18 E7Δ32-42, and/or MAGE-A397-178/190-295, and/or CysOVA257-294, said composition further comprising an adjuvant which is a Toll-like receptor ligand selected from imiquimod and poly-ICLC.
EFFECT: use of this composition provides stimulation of immune response against corresponding antigenic epitopes, including stimulation of memory T-cell formation.
9 cl, 10 dwg
| Title |
Year |
Author |
Number |
| RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMA VIRUS EPITOPES, PROTEIN EMBEDDED ADENYLATECYCLASE OR ITS FRAGMENT, ITS THERAPEUTIC APPLICATION |
2005 |
- Preville Khav'Er-Ehdmond-Ehduard
- Leklerk Klod
- Ladant Daniel
- Timmerman Benedikt
|
RU2441022C2 |
| MUTANT POLYPEPTIDES SUAA AND POLYPEPTIDE DERIVATIVES SUITABLE FOR DELIVERY OF IMMUNOGENIC MOLECULES IN CELL |
2010 |
- Sebo Peter
- Ositskova Adriana
- Masin Irzhi
- Fajol Katrin
- Krusek Yan
- Basler Marek
- Leklerk Klod
- Ositska Radim
|
RU2585216C2 |
| COMPOSITIONS CAUSING SPECIFIC RESPONSE OF CYTOTOXIC T-LYMPHOCYTES, INCLUDING LYMPH-ABLATIVE COMPOUND AND MOLECULE WHICH CONTAINS ANTIGEN SEQUENCES AND IS TARGETED AT SPECIALISED ANTIGEN-PRESENTING CELLS |
2007 |
- Previll' Ksav'E
- Timmerman Benedikt
|
RU2448729C2 |
| METHOD OF TREATING CERVICAL CANCER |
2021 |
- Sung, Young Chul
- Woo, Jung Won
- Park, Jong Sup
- Youn, Jin Won
|
RU2832963C2 |
| STABLE VECTOR OF CONSTITUTIVELY HIGH EXPRESSION FOR OBTAINING HPV VACCINE, AND RECOMBINANT LACTIC ACID BACTERIA TRANSFORMED BY THIS VECTOR |
2010 |
- Sjung Moon-Khi
- Poo Kharuong
- Li Il' Khan
|
RU2492240C2 |
| COMBINATION OF POXVIRUS ENCODING HUMAN PAPILLOMA VIRUS POLYPEPTIDES, AND IL-2 WITH ANTI-PD-L1 ANTIBODY |
2020 |
- Bendjama Kaidre
- Brandely Talbot Maud
- Tavernaro Annette
|
RU2824962C1 |
| MUTANT POLYMERASES OF HEPATITIS B VIRUS |
2012 |
- Marten Perrin
- Silvestr Natali
- Marshan Zhan-Baptist
|
RU2625021C2 |
| MODIFIED ADENYLATE CYCLASE BORDETELLA CONTAINING CD11b/CD18 INTERACTION DOMAIN OR CD11B/CD18 INTERACTION DOMAIN DEFICIENT, AND ITS APPLICATION |
2004 |
- Leklerk Klod
- Ehl'-Azami Ehl'-Idrissi Mokhammed
- Ladan Daniel'
- Bosh Sesil'
- Sebo Peter
- Louchka Irina
- Osichka Radim
|
RU2421241C2 |
| PREVENTIVE CANCER VACCINE |
2004 |
- Agadzhanjan Majkl G.
- Gochikjan Anait
|
RU2385163C2 |
| IMMUNOPROPHYLACTIC CANCER VACCINE |
2004 |
- Agadzhanjan, Majkl, G.
- Gochikjan, Anait
|
RU2556128C2 |
