FIELD: biochemistry; medicine.
SUBSTANCE: disclosed is a composition for immunotherapeutic treatment or prophylaxis of a condition which is a consequence of infection with HPV16 and/or HPV18, comprising a pharmaceutically acceptable base or composition and an effective amount of at least one vector from a protein CyaA Bordatella pertussis or a fragment thereof, carrying polypeptides containing epitope HPV16 E7Δ30-42 and epitope HPV18 E7Δ32-42, and/or MAGE-A397-178/190-295, and/or CysOVA257-294, said composition further comprising an adjuvant which is a Toll-like receptor ligand selected from imiquimod and poly-ICLC.
EFFECT: use of this composition provides stimulation of immune response against corresponding antigenic epitopes, including stimulation of memory T-cell formation.
9 cl, 10 dwg
