RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMA VIRUS EPITOPES, PROTEIN EMBEDDED ADENYLATECYCLASE OR ITS FRAGMENT, ITS THERAPEUTIC APPLICATION Russian patent published in 2012 - IPC C07K14/25 C12N15/37 C12N15/63 C12N5/10 A61K39/12 A61P31/20 C12Q1/70 

Abstract RU 2441022 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology, virology and medicine. What is disclosed is a recombinant protein containing one or more polypeptides carrying one or more epitopes of one or more human papilloma virus HPV antigens. Said polypeptides are embedded in one or various permissive sites of adenylatecyclase (CyaA) or its fragments. What is also disclosed is the polypeptide coding such protein and their use in expression systems for producing immunogenic compositions and drugs. The invention can be used in medicine.

EFFECT: CyaA fragment possesses the property of said adenylatecyclase protein for targeted interaction with antigen-presenting cells.

60 cl, 21 dwg, 1 tbl, 3 ex

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Authors

Preville Khav'Er-Ehdmond-Ehduard

Leklerk Klod

Ladant Daniel

Timmerman Benedikt

Dates

2012-01-27Published

2005-03-18Filed