Show metadata Hide metadata

(19)

(11)

2 315 041

(13)

(51)

IPC

C07D215/14(2006-01-01)

C07C309/65(2006-01-01)

C07D215/36(2006-01-01)

C07C229/40(2006-01-01)

C07D215/22(2006-01-01)

C07D401/06(2006-01-01)

C07D401/12(2006-01-01)

C07C205/49(2006-01-01)

C07C237/36(2006-01-01)

C07C43/205(2006-01-01)

A61K31/47(2006-01-01)

A61P19/02(2006-01-01)

A61P29/00(2006-01-01)

A61P37/08(2006-01-01)

(21) (22)

Application

2004135304/04, 2003-04-15

(24)

Start date

2003-04-15

(22)

Actual filing date

2003-04-15

(45)

Published

2008-01-20

(72)

Inventor

Lassua Mari-AgnesKner LoranDemod T'ErriDe Lavelej FransuazKozhezh T'ErriRut'E Sil'VehnGijomet Zheral'D

(73)

Holder

Jusibi, S.A.

DERIVATIVES OF 2,6-QUINOLINYL AND 2,6-NAPHTHYL, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, THEIR USING AS VLA-4 INHIBITORS AND INTERMEDIATE COMPOUNDS Russian patent published in 2008 - IPC C07D215/14 C07C309/65 C07D215/36 C07C229/40 C07D215/22 C07D401/06 C07D401/12 C07C205/49 C07C237/36 C07C43/205 A61K31/47 A61P19/02 A61P29/00 A61P37/08

Abstract RU 2315041 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): wherein X represents nitrogen atom (N) or -CH; R¹ represents cycloalkyl, aryl, heterocycle, aralkyl, heterocyclic alkyl or oxy-derivative, or group of the formula: ; R² represents -NR⁴R⁵, -OR⁴; R³ represents tetrazole, -CN, -CH₂OH or -CO-R⁷; R⁴ represents hydrogen atom (H), -G₁-R⁸ or group of the formula: or wherein G₁ represents -CO, -CH₂, -SO₂; R⁵ represents H, (C₁-C₄)-alkyl; R⁷ represents hydroxy-, amino-, hydroxylamino- or oxy-derivative or amino-derivative; R⁸ represents aryl, heterocycle, cycloalkyl, aralkyl. Also, invention describes a pharmaceutical composition designated for treatment of VLA-4-dependent inflammatory diseases based on proposed compounds. Also, invention considers using these compounds for treatment and preparing an agent for treatment of VLA-4-dependent inflammatory diseases. Invention provides synthesis of novel compounds possessing useful biological properties.

EFFECT: improved and valuable medicinal properties of compounds and pharmaceutical composition.

26 cl, 9 tbl, 5 ex

Similar patents RU2315041C2

Title	Year	Author	Number
1,2,4-SUBSTITUTED PIPERIDINES AND A METHOD OF THEIR SYNTHESIS, INTERMEDIUM COMPOUNDS OF PIPERIDONE AND A METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON NEW COMPOUNDS	1992	Val'Ter Shilling Sil'Vio Ofner Sim Dzh.Veenstra	RU2114829C1
DERIVATIVES OF IMIDAZOLE	1997	Ding Charl'Z Z. Khant Dzhon T. Kim Sung-Khun Mitt Tumas Bkhide Radzhiv Lefteris Katerina	RU2225405C2
SELECTIVE HERBICIDES BASED ON ARYLSULFONYLAMINOCARBONYL TRIAZOLINES	2001	Fojkht Diter Damen Peter Dreves Mark Vil'Khel'M Ponttsen Rol'F Kremer Matias Mjuller Klaus-Khel'Mut	RU2277335C2
2,6-SUBSTUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS	2005	Lim Sungtaek Kharris Kejt Dzhon Stefani Dehvid Gardner Charl'Z Dzh. Tsao Bin Boffi Rehj Gillespi Timoti A. Agiar Zhuasi K. Khant Khejzel Dzh. Desho Ehl'Za A.	RU2417990C2
TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, USEFUL AS BB2 ANTAGONIST	2008	Khisamiti Khirojuki Simada Itsuro Isikhara Tsukasa Takuva Tomofumi Simizu Takafumi Isikava Noriko Maeno Kioiti Seki Norio	RU2479578C2
CYCLIC INHIBITORS OF PROTEIN-TYROSINE KINASE	2000	Das Dzhagabandkhu Padmanabkha Ramesh Chen Ping Norris Derek Dzh. Dovejko Artur M.P. Behrrish Dzhoehl S. Vitjak Dzhon	RU2312860C2
HETEROCYCLIC DIHYDROPYRIMIDINE COMPOUNDS	2000	Ehtuol Karnehjl S. Vakkaro Uehjn Llojd Dzhon Finlej Khizer Jan Lin S. Bkhandaru Rao	RU2296766C2
PIPERAZINE DERIVATIVE	2016	Sugane, Takashi Makino, Takuya Yamashita, Daisuke Yonetoku, Yasuhiro Tanabe, Daisuke Mihara, Hisashi Asai, Norio Osoda, Kazuhiko Shimizu, Takafumi Moritomo, Hiroyuki Sugasawa, Keizo Maeno, Kyoichi Hosogai, Naomi	RU2731913C2
FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS AND USE THEREOF	2017	U, Frenk	RU2732127C1
NOVEL 1,2-BIS-SULPHONAMIDE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR	2011	Yuan Khajtsin Bird Richard L. Lyu Syaosya Donello Dzhon E. Visvanat Veena Garst Majkl E.	RU2654213C9

RU 2 315 041 C2

Authors

Lassua Mari-Agnes

Kner Loran

Demod T'Erri

De Lavelej Fransuaz

Kozhezh T'Erri

Rut'E Sil'Vehn

Gijomet Zheral'D

Dates

2008-01-20—Published

2003-04-15—Filed