FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel compounds of the formula (I): wherein X represents nitrogen atom (N) or -CH; R1 represents cycloalkyl, aryl, heterocycle, aralkyl, heterocyclic alkyl or oxy-derivative, or group of the formula:
; R2 represents -NR4R5, -OR4; R3 represents tetrazole, -CN, -CH2OH or -CO-R7; R4 represents hydrogen atom (H), -G1-R8 or group of the formula:
or
wherein G1 represents -CO, -CH2, -SO2; R5 represents H, (C1-C4)-alkyl; R7 represents hydroxy-, amino-, hydroxylamino- or oxy-derivative or amino-derivative; R8 represents aryl, heterocycle, cycloalkyl, aralkyl. Also, invention describes a pharmaceutical composition designated for treatment of VLA-4-dependent inflammatory diseases based on proposed compounds. Also, invention considers using these compounds for treatment and preparing an agent for treatment of VLA-4-dependent inflammatory diseases. Invention provides synthesis of novel compounds possessing useful biological properties.
EFFECT: improved and valuable medicinal properties of compounds and pharmaceutical composition.
26 cl, 9 tbl, 5 ex
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Authors
Dates
2008-01-20—Published
2003-04-15—Filed