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(19)

(11)

2 312 860

(13)

(51)

IPC

C07D277/42(2006-01-01)

C07D277/48(2006-01-01)

C07D417/12(2006-01-01)

A61K31/426(2006-01-01)

A61P37/00(2006-01-01)

A61P35/00(2006-01-01)

A61P19/02(2006-01-01)

(21) (22)

Application

2005107463/04, 2000-04-12

(24)

Start date

2000-04-12

(22)

Actual filing date

2000-04-12

(45)

Published

2007-12-20

(72)

Inventor

Das DzhagabandkhuPadmanabkha RameshChen PingNorris Derek Dzh.Dovejko Artur M.P.Behrrish Dzhoehl S.Vitjak Dzhon

(73)

Holder

Bristol-Maers Skvibb Kompani

CYCLIC INHIBITORS OF PROTEIN-TYROSINE KINASE Russian patent published in 2007 - IPC C07D277/42 C07D277/48 C07D417/12 A61K31/426 A61P37/00 A61P35/00 A61P19/02

Abstract RU 2312860 C2

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to novel cyclic compounds of the formula (I) and (II) or tier pharmaceutically acceptable salts wherein radical values given in formula (I) and (II) are indicated in the invention description. Also, invention relates to a pharmaceutical composition containing at least one compound of the formula (I), and to using these compounds for preparing a drug. Invention provides synthesis of novel compounds and preparing a compositions containing hereof that possess inhibitory activity with respect to protein-tyrosine kinase.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.

24 cl, 3 tbl, 582 ex

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RU 2 312 860 C2

Authors

Das Dzhagabandkhu

Padmanabkha Ramesh

Chen Ping

Norris Derek Dzh.

Dovejko Artur M.P.

Behrrish Dzhoehl S.

Vitjak Dzhon

Dates

2007-12-20—Published

2000-04-12—Filed