FIELD: organic chemistry, medicine, biochemistry.
SUBSTANCE: invention relates to a novel crystalline form of 3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidine-1-yl}-3-oxopropionitrile. This form shows characteristic peaks in powder roentgenogram obtained by using Cu as radiation source and expressed as degrees two-theta at about 5.7; 16.1; 20.2 and 20.5. Also, invention relates to a method for preparing this form and its using in preparing medicinal agents in treatment or prophylaxis of diseases mediate by protein-tyrosine-kinases, such as JAK3. Method for preparing this form involves interaction of 3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropionitrile with citric acid.
EFFECT: improved preparing method, valuable properties of compound.
5 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
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