NOVEL (HETERO)ARYL-SUBSTITUTED PIPERIDINYL DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2021 - IPC C07D471/04 C07D487/04 C07D495/04 A61K31/519 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I):

where: ♦ R₁ denotes a phenyl group or a thienyl group, ♦ R₂ denotes a hydrogen atom or a halogen atom, n denotes an integer equal to 0, 1 or 2, ♦ J represents a -C(O)- group, -CH(R₃)- group or -SO₂- group, ♦ R₃ represents a hydrogen atom or a linear or branched (C₁-C₆)alkyl group, ♦ K represents a bond or -Cy₁- group, ♦ L represents a -Cu₂ group or -CH₂-Cy₂ group, ♦ W represents a group where:

■ represents

or ,

■ X represents carbon atom or a nitrogen atom, ■ R₄ represents a hydrogen atom, a halogen atom, a linear or branched (C₁-C₆)alkyl group, a linear or branched (C₂-C₆)alkenyl group, a linear or branched (C₂-C₆)alkynyl group, -Y₁-NR₆R₇ group, -Y₁-OR₆ group, a linear or branched halogen (C₁-C₆)alkyl group, an oxo group, -Y₁-Cu₃ group, -Cy₃-R₇ group, -Cy₃-OR₇ group, or -Y₁-NR₆-C(O)-R₇ group, ■ R₅ represents a hydrogen atom, a halogen atom, or a linear or branched (C₁-C₆)alkyl group, ■ R₆ is a hydrogen atom or a linear or branched (C₁-C₆) alkyl group, ■ R₇ is a hydrogen atom, a linear or branched (C₁-C₆)alkyl group or -Y₂-Cy₄ group, ■ Y₁ and Y₂ independently represent a bond or a linear or branched (C₁-C₄)alkylene group (values of the remaining radicals see paragraph 1 of formula), which is a USP7 protein activity inhibitor, as well as pharmaceutical compositions and combinations containing said protein.

EFFECT: novel (hetero)aryl-substituted piperidinyl derivatives, a method for preparing them and pharmaceutical compositions containing them are disclosed.

32 cl, 1 tbl, 1013 ex