FIELD: chemistry.
SUBSTANCE: invention provides an amorphous solid dispersion comprising a taxane or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable polymer, and a pharmaceutically acceptable surfactant, which increases solubility. Method of producing a solid dispersion is also disclosed.
EFFECT: present invention also provides a tablet characterised by good solubility, bioavailability and stability, which comprises an amorphous solid dispersion, an intragranular excipient and an extragranular excipient.
29 cl, 9 dwg, 16 tbl, 25 ex
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