CCR-2 ANTAGONIST SALT Russian patent published in 2008 - IPC C07D471/04 A61K31/4375 A61P29/00

Abstract RU 2317295 C1

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to a novel compound - ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine succinate of the formula: that possesses property of CCR-2 antagonist. Also, invention relates to a method for modulation of activity of chemokine receptors and a method for treatment, improvement, control and reducing risk of inflammatory and immunoregulatory disorder or disease, and to a method for improvement, control and reducing risk of rheumatic arthritis.

EFFECT: valuable medicinal properties of compound.

4 cl, 3 tbl, 5 ex

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RU 2 317 295 C1

Authors

Dzhensen Mark

Larsen Robert

Sidler Dehniel Richard

Dates

2008-02-20—Published

2004-10-25—Filed