METHOD FOR COMPLEX THERAPY IN PATIENTS WITH SKIN MELANOMA Russian patent published in 2008 - IPC A61B17/00 A61K35/14 A61K31/282 A61K31/675 A61K31/196 A61P35/00 A61B8/06 A61M1/36 A61N5/10 

FIELD: medicine, oncology.

SUBSTANCE: the present innovation deals with surgical therapy and chemoradiation therapy. Moreover, in pre-surgical period a patient's blood plasma should be incubated with the following chemopreparations: cisplatin 10 mg, methotrexate 25 mg, cyclophosphan 600 mg in a thermostat at 37°C for 30 min. Then it is important to inject the incubated plasma into a patient's subcutaneous fatty fiber due to paracentesis from 4 sides through the points marked under US control being beyond vascular system just under the focus of malignant growth. During the same day it is necessary to start gamma-therapy at the dosage of 2.4 Gy daily for 15 d, 2 d later one should carry out operation in the volume of wide dissection of the primary focus. The innovation enables to prolong the life period in patients, prevent tumor dissemination in the course of operation, decrease the risk for the development of disease relapses after surgical dissection of the primary tumor, creates the chance for direct supply of chemopreparations towards tumor focus and, also, develops conditions for their prolonged local impact.

EFFECT: higher efficiency of therapy.

4 dwg, 1 ex