METHOD OF TREATING ADVANCED AND RECURRENT SKIN CANCER Russian patent published in 2010 - IPC A61M1/16 A61K35/16 A61K31/282 A61K31/196 A61K38/21 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used in treating the patients with advanced and recurrent skin cancer. Substance of the method consists that the patient is exposed to the discrete gravity plasmapheresis; blood 400 ml is drawn once; prepared autoplasma is divided on two portions, each 150 ml whereto 30 ml of erythromass and 10 portions, each 10 ml. All the portions are collected in sterile containers and frozen at t =-24°C. Then wide excision of a tumour nidus follows. Next day, erythrocyte-enriched autoplasma is incubated with cisplatin - 100 mg, methotrexate - 50 mg, bleomycine - 15 mg in a thermostat for 30 min at t=37°C and introduced drop-by-drop intravenously. It is combined with intradermal paratumour immunotherapy with Lifeferon pre-incubated from one of the portions of the defrosted plasma 10 ml within 10 days.

EFFECT: use of the invention allows reducing risk of recurrent tumour following surgical excision of a primary tumour due to enabled direct immunomodulator delivery to the tumour nidus and its prolonged local action.

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