FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to pharmaceutical compositions containing inhibitor of cholesterol esters-transporting protein (CETP) and a water-insoluble additive increasing its concentration. As CETP inhibitor invention uses S-{2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl}-2-methylpropanethioate or a prodrug that forms in vivo S-{2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl}-thiol. A water-insoluble additive increasing the concentration of CETP inhibitor represents crospovidon. Indicated compositions show improved bioavailability in medium wherein they are used that allows using in methods for treatment of cardiovascular disorders.
EFFECT: improved and valuable pharmaceutical properties of compositions.
13 cl, 11 tbl, 5 dwg, 9 ex
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| INHIBITOR OF ACTIVITY OF CHOLESTEROL ESTERIFIED TRANSPORT PROTEIN, PROPHYLACTIC OR THERAPEUTIC AGENT, DERIVATIVES OF BIS-(2-AMIDOPHENYL)-DISULFIDE OR AMIDOTHIOPHENOL | 1998 |
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