METHOD OF PRODUCING AROMATIC THIOL DERIVATIVES DURING HYDROGENATION OF DISULPHIDES Russian patent published in 2017 - IPC C07C319/06 C07C323/40 C07C327/30 C07D277/64 

FIELD: chemistry.

SUBSTANCE: invention relates to methods of producing thiophenols during reaction of corresponding disulphide with hydrogen in presence of a heterogeneous hydrogenation catalyst based on a transition metal. In particular, method of producing a compound of formula (I') involves reaction of a compound of formula (II'), wherein R is H or with H₂ in presence of a heterogeneous hydrogenation catalyst based on a transition metal, where heterogeneous hydrogenation catalyst based on a transition metal is a Raney catalyst, Pd/C, Pd(OH)₂/C, nanoparticles of palladium (0), micro-encapsulated in a polyurea matrix, Au/TiO₂, Rh/C, Ru/Al₂O₃, Ir/CaCO₃, Pt/C or mixture thereof. When reaction is carried out in presence of an acylating reagent, such as anhydride or halide of carboxylic acid, acylated thiophenol is obtained.

EFFECT: pharmaceutically active compound S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]-2-methylthiopropionate is obtained during said method.

20 cl, 16 ex, 1 tbl