INHIBITOR OF ACTIVITY OF CHOLESTEROL ESTERIFIED TRANSPORT PROTEIN, PROPHYLACTIC OR THERAPEUTIC AGENT, DERIVATIVES OF BIS-(2-AMIDOPHENYL)-DISULFIDE OR AMIDOTHIOPHENOL Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to an inhibitor of activity of cholesterol esterified transport protein comprising as an active component the compound presented by the formula (I) where R means direct or branched alkyl group; lower halogenalkyl group; substituted or unsubstituted cycloalkyl group; substituted or unsubstituted cycloalkylalkyl group; substituted or unsubstituted aryl group, or substituted or unsubstituted heterocyclic group; X₁, X₂, X₃, X₄ can be similar or different and each means hydrogen atom, halogen atom, lower alkyl group, lower halogenalkyl group; lower alkoxy-group; cyano-group; nitro-group; Y means CO- and Z means hydrogen atom or mercapto-protecting group, or its pharmaceutically acceptable salt or hydrate, or solvate. Compounds presented by the formula (I) can increase the level of high density lipoproteins (HDL) and in the same time decrease the level of low density lipoproteins (LDL) by selective inhibition of activity of cholesterol esterified transport protein and therefore as suggested they can be used as prophylactic or therapeutic agents of new type for treatment of atherosclerosis or hyperlipidemia. EFFECT: new compounds indicated above, valuable medicinal properties. 24 cl, 48 tbl