DERIVATIVES OF TETRAHYDROCARBAZOLE AND THEIR PHARMACEUTICAL USING Russian patent published in 2008 - IPC C07D209/88 C07D401/12 C07D403/12 C07D417/12 A61K31/403 A61K31/4439 A61K31/429 A61K31/506 A61P31/20 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel derivatives of tetrahydrocarbazole of the formula (I): wherein n = 0, 1 or 2; X represents -NH or oxygen atom (O); each R is a similar or different radical and chosen independently from group consisting of halogen atom, halogenalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -R¹⁰-cycloalkyl, -OR², -R¹⁰OR², -R¹⁰C(O)R², -C(O)R², -CO₂R², -R¹⁰CO₂R², -R¹⁰SO₂R², -S(O)_mR², cyano- or nitro-group; each R¹ is a similar or different radical and chosen independently from group consisting of halogen, halogenalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -R¹⁰-cycloalkyl, -OR², -R¹⁰OR², -R¹⁰C(O)R², -C(O)R², -CO₂R², -R¹⁰CO₂R², -R¹⁰SO₂R², -S(O)_mR², cyano- or nitro-group and wherein each m means 2 independently; each R¹⁰ is a similar or different radical and chosen independently from alkylene; each p and q is chosen independently from 0, 1, 2, 3, 4 or 5; each R² is a similar or different radical and chosen independently from group consisting of hydrogen atom (H), alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -R¹⁰-cycloalkyl and -R¹⁰OH; ring A represents phenyl, naphthyl or heteroaryl wherein heteroaryl represents monocyclic 5-7-membered aromatic ring or condensed bicyclic aromatic ring system consisting of two such aromatic rings that comprise one or two nitrogen atoms and/or sulfur atoms, and to their pharmaceutically acceptable salts, solvates, esters and amides. Compounds of the formula (I) possess effect against disorders caused by HPV-infection and useful in treatment of human papilloma. Also, invention relates to a pharmaceutical composition based on compounds of the formula (I) and its using in preparing drugs for their using in treatment and prophylactic of states or disorders caused by HPV-infection.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.