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2 318 819

(13)

(51)

IPC

C07D277/40(2006-01-01)

(21) (22)

Application

2006142733/04, 2006-12-04

(24)

Start date

2006-12-04

(22)

Actual filing date

2006-12-04

(45)

Published

2008-03-10

(72)

Inventor

Gladysheva Tamara KhaimovnaGorelik Mikhail Viktorovich

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Nauchnyj Tsentr Institut Organicheskikh Poluproduktov I Krasitelej"

METHOD FOR PREPARING 2-AMINO-5-METHYLTHIAZOLE Russian patent published in 2008 - IPC C07D277/40

Abstract RU 2318819 C1

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of 2-amino-5-methylthiazole used as an intermediate compound in synthesis of drugs. Method for synthesis of 2-amino-5-methylthiazole involves the following steps: chlorination reaction of propionic aldehyde with sulfuryl chloride, successive addition of lower alcohol and alkali aqueous solution to alkaline pH value of medium, separation of organic phase containing 2-chloropropionic aldehyde acetal, condensation of acetal with thiourea. Organic phase is added directly to thiourea in acid aqueous solution. Method provides increasing yield of the end product and to simplify the process.

EFFECT: improved method of synthesis.

1 cl, 3 ex

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RU 2 318 819 C1

Authors

Gladysheva Tamara Khaimovna

Gorelik Mikhail Viktorovich

Dates

2008-03-10—Published

2006-12-04—Filed