DERIVATIVES OF POLYSUBSTITUTED 2-AMIDO-4-PHENYLTHIAZOLES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1999 - IPC

Abstract RU 2125569 C1

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention relates to compounds of the formula (I) where Y means 3-quinolinyl group or 2-indolyl group of the formula (II) where R means hydrogen, acetyl group or group CH2COOR′ being R′ means hydrogen or C1-C4-alkyl; X means (hetero)aryl radical taken from a group given in description; Z means hydrogen, C1-C4-alkyl or benzyl, and their salts and solvates also. Invention relates to also a method of synthesis of compounds of the formula (I), intermediate compounds for synthesis and a pharmaceutical composition based on compounds said. Synthesized compounds show agonism with respect to cholecystokinin receptors and can be used for treatment of patients with disorders caused by cholecystokinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 34 ex

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RU 2 125 569 C1

Authors

Rober Buazhegrehn

Rozhe Broden

Daniel' Freehl'

Daniell' Gjulli

Zhan-Sharl' Molimard

Dominik Olliero

Dates

1999-01-27Published

1994-02-18Filed