FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention relates to compounds of the formula (I) where Y means 3-quinolinyl group or 2-indolyl group of the formula (II) where R means hydrogen, acetyl group or group CH2COOR′ being R′ means hydrogen or C1-C4-alkyl; X means (hetero)aryl radical taken from a group given in description; Z means hydrogen, C1-C4-alkyl or benzyl, and their salts and solvates also. Invention relates to also a method of synthesis of compounds of the formula (I), intermediate compounds for synthesis and a pharmaceutical composition based on compounds said. Synthesized compounds show agonism with respect to cholecystokinin receptors and can be used for treatment of patients with disorders caused by cholecystokinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 34 ex
Title |
Year |
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Number |
DERIVATIVES OF 5-ACYLAMINO-1,2,4-THIADIAZOLES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING AFFINITY TO CHOLECYSTOKININ RECEPTORS |
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1993 |
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1993 |
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