FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention relates to compounds of the formula (I) 
where Y means 3-quinolinyl group or 2-indolyl group of the formula (II) 
where R means hydrogen, acetyl group or group CH2COOR′ being R′ means hydrogen or C1-C4-alkyl; X means (hetero)aryl radical taken from a group given in description; Z means hydrogen, C1-C4-alkyl or benzyl, and their salts and solvates also. Invention relates to also a method of synthesis of compounds of the formula (I), intermediate compounds for synthesis and a pharmaceutical composition based on compounds said. Synthesized compounds show agonism with respect to cholecystokinin receptors and can be used for treatment of patients with disorders caused by cholecystokinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 34 ex
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Year |
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Number |
| DERIVATIVES OF 5-ACYLAMINO-1,2,4-THIADIAZOLES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING AFFINITY TO CHOLECYSTOKININ RECEPTORS |
1994 |
- Daniel' Freel'
- Daniel' Gjulli
- Rober Buaszhegrehn
- Alen Badork
- Zhan-P'Er Bra
- P'Er Depejru
|
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1998 |
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- Frel' Daniel'
- Gjulli Daniel'
|
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| SUBSTITUTED 3-ACYLAMINO-5-PHENYL-1,4-BENZODIAZEPIN 2-ONE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND INTERMEDIATE PRODUCT |
1995 |
- Alen Badork
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RU2142948C1 |
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1994 |
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- Daniell Gjuli
- Fransis Zhanzhan
- Zhan-Sharl' Molimar
- Rober Buazhgrehn
|
RU2140912C1 |
| BRANCHED ALKYLAMINO DERIVATIVES OF THIAZOLE OR THEIR POTENTIAL STEREOISOMERS OR THEIR ADDITIVE SALTS WITH MINERAL OR ORGANIC ACID, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY IN RESPECT WITH FACTOR OF RELEASING OF CORTICOTROPIC HORMONE AND ALKYLAMINO DERIVATIVES OF THIAZOLE AS INTERMEDIATE COMPOUNDS |
1993 |
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1993 |
- Lois Fulon
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1995 |
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| INDOLINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION |
1992 |
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1996 |
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| N-ALKYLENEPIPERIDINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, OPTICALLY PURE DERIVATIVES OF N-ALKYLENEPIPERIDINE |
1992 |
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RU2089547C1 |
