ANALOGUES OF VITAMIN D, COMPOSITIONS CONTAINING INDICATED ANALOGUES AND THEIR USING Russian patent published in 2008 - IPC C07C401/00 A61K31/59 A61P5/20 

FIELD: organic chemistry, vitamins, medicine.

SUBSTANCE: invention relates to analogues of vitamin D of the general formula (I): wherein R₁ and R₂ mean halogen atom, (C₁-C₆)-hydrocarbon radical possibly substituted with 1, 2 -OH groups, 1, 2 fluorine (F) atoms, or R₁ and R in common means (C₃-C₆)-carbocycle, or R₁ and R₂ in common mean a direct bond, or R₁ and R₂ in common mean hydrogen atom (H); R₃ means H or (C₁-C₃)-hydrocarbon radical; X means (E)-ethylene, (Z)-ethylene, ethynylene or a bond; Y and Z mean H, -CH₃; A means -OH, F or H; B means -CH₂- or H₂ under condition that compound of the formula (I) doesn't mean 3(S)-hydroxy-9,10-secocholesta-5(Z),7(E),10(19),22(E),24-pentaene. Compounds elicit strong suppression effect on secretion of parathyroid hormone and useful in treatment of secondary hyperparathyroiditis possibly associated with renal insufficiency.

EFFECT: valuable medicinal properties of vitamin D analogues.

19 cl, 2 tbl, 36 ex