NOVEL DERIVATIVES OF PYRROLIDINIUM Russian patent published in 2008 - IPC C07D409/14 C07D405/12 C07D207/12 C07D417/14 C07D409/06 A61K31/4025 A61K31/40 A61P13/10 A61P11/00 A61P1/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel derivatives of pyrrolidinium of the general formula (I): possessing antagonistic effect with respect to muscarinic receptors M3 wherein B means phenyl or thienyl group; each radical among R¹, R² and R means independently hydrogen, fluorine, chlorine atom or hydroxyl; n means a whole number from 0 to 1; A means group chosen from groups -CH₂ and -O-; m means a whole number from 0 to 6; R means (C₁-C₈)-alkyl; X^- represents a pharmaceutically acceptable anion of mono- or multibasic acid, and involving all separate stereoisomers and their mixtures. Also, invention relates to methods for synthesis of such compounds, pharmaceutical compositions containing such compounds and to their using in therapy as antagonists of muscarinic receptors M3.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

17 cl, 51 ex