FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to pulmonology and represents a combination containing (a) PDE4 inhibitor and (b) antagonist of muscarine receptors M3 that represents (R)-(2-hydroxy-2,2-dithiene-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniumbicyclo[2.2.2]octane in the form of salt with anion X which is a pharmaceutically acceptable anion of a mono-or polyvalent acid.
EFFECT: invention provides improved bronchodilatory effect.
20 cl, 7 ex
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