FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a new method for synthesis of derivative of thieno[3,2-c]pyridine of the formula (1): 
(ticlopidine and clopidogrel). Method involves interaction of compound of the formula (2e): 
with compound of the formula (3): 
or its salt wherein R represents hydrogen atom or methoxycarbonyl; each among X' and Y' represents independently chlorine, bromine atom, methanesulfonyl or p-toluenesulfonyl, and to novel intermediate compounds and methods for their synthesis. Ticlopidine and clopidogrel possess the high inhibitory activity with respect to blood platelets aggregation and antithrombosis activity.
EFFECT: simplified process of synthesis, valuable medicinal properties of compounds.
15 cl, 32 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CLOPIDOGREL PROCESS AND INTERMEDIATE COMPOUNDS THEREFOR | 2005 |
|
RU2357970C1 |
| GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE INGREDIENT | 2008 |
|
RU2450001C2 |
| COMPOUNDS WITH HYDROXYCARBONYL-HALOGENALKYL BY-SIDE CHAINS | 2000 |
|
RU2247106C2 |
| TRICYCLIC DERIVATIVES OR THEIR PHARMACEUTICAL SALTS, METHOD OF OBTAINING THEM AND THEIR PHARMACEUTICAL COMPOUNDS | 2004 |
|
RU2326864C2 |
| METHOD OF PRODUCING ESOMEPRAZOLE AND SALTS THEREOF | 2006 |
|
RU2382777C2 |
| HETEROCYCLIC DERIVATIVES AND USE THEREOF | 2014 |
|
RU2681849C2 |
| HETEROCYCLIC DERIVATIVES AND USE THEREOF | 2015 |
|
RU2711502C2 |
| NOVEL TRICYCLIC DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVE | 2009 |
|
RU2470934C1 |
| METHOD OF PRODUCING CLOPIDOGREL AND DERIVATIVES THEREOF | 2009 |
|
RU2469039C2 |
| NOVEL BENZAMIDE DERIVATIVES | 2011 |
|
RU2536688C2 |
