FIELD: chemistry.
SUBSTANCE: according to the invention, optically pure esomeprazole and its salt can be easily produced by dissolving (S)-(-)-binol, a weak base and a racemic form of omeprazole in a mixture of a water miscible solvent and water at high temperature, cooling the mixed solution to crystallisation of the inclusion esomeprazole complex and (S)-(-)-binol and removal of the (S)-(-)-binol fragment from the crystallised inclusion complex obtained at step A.
EFFECT: design of an improved method of separating optical isomers of omeprazole, which allows for obtaining optically pure end product.
13 cl, 2 dwg, 3 tbl, 20 ex
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