COMPOUNDS WITH HYDROXYCARBONYL-HALOGENALKYL BY-SIDE CHAINS Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a new compound of the general formula (2) and a method for its preparing wherein R₁ represents hydrogen atom or salt-forming metal; R₂ represent a direct or branched (C₁-C₇)-halogenalkyl group; m represents a whole number from 2 to 14; n represents a whole number from 2 to 7; A represents a group taken among the following formulae: (3) , (4) ,

(5) ,

(6) ,

(17) , (18) , (19) , (20) , (23) , (25) and (26) wherein R₃ in formula (6) represents a direct or branched group (C₁-C₅)-alkyl group; R₈ in formulae (18) and (20) represents a direct or branched (C₁-C₅)-alkyl group, a direct or branched (C₂-C₅)-alkenyl group or a direct or branched (C₂-C₅)-alkynyl group; in formula (23) each R₂₁, R₂₂, R₂₃ and R₂₄ represents independently hydrogen atom, a direct or branched (C₁-C₅)-alkyl group, a direct or branched (C₁-C₇)-halogenalkyl group, halogen atom or acyl group; in formulae (25) and (26) X represents halogen atom; or enantiomers of compound, or hydrates, or pharmaceutically acceptable salts of compound, or its enantiomers. Also, invention relates to a pharmaceutical composition containing indicated compound as an active component and to a therapeutic agent used against breast cancer based on thereof.

EFFECT: valuable medicinal properties of compounds.

10 cl, 2 tbl, 39 ex