TEMOSOLOMIDE-CONTAINING SYSTEM FOR CONTROLLED RELEASE Russian patent published in 2008 - IPC A61K31/4188 A61K47/30 A61K9/22 A61P35/00 

Abstract RU 2322979 C2

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a system for controlled release of temosolomide that comprises 10 wt.-% of temosolomide and biodegradable polymeric material representing polyanhydride. This polyanhydride is synthesized by condensation of 3,4-bis-(p-carboxyphenoxy)propane with sebacic acid in their ratio = 20:80, respectively. The system for controlled release of temosolomide represents implanted tablets. Implants are able to release anticancer preparation temosolomide by the controlled manner in vivo for prolonged time from 1 h to 4 weeks.

EFFECT: improved and valuable medicinal and pharmaceutical properties of system.

13 cl, 1 tbl, 2 dwg, 8 ex

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RU 2 322 979 C2

Authors

Vang Jongfehng

Fehj Dan

Dates

2008-04-27Published

2003-09-29Filed