FIELD: biotechnologies.
SUBSTANCE: invention provides hemihydrate of naltrexone base that has characteristic peaks at powder X-ray diffraction pattern at the angles 2θ 7.1, 9.4, 12.7, 13.5, 14.3, 14.9, 16.9, 21.6, 22.2, 24.2, 25.6 and 27.7°. Moreover the invention pertains to the method of its obtaining as well as to the method of obtaining microspheres containing naltrexone base.
EFFECT: hemihydrate of naltrexone base with high solvability in organic solvents, simplified and cheap method for obtaining polymorph of naltrexone base, method for obtaining microspheres with reduced toxic properties and improved profile of naltrexone release.
5 cl, 2 tbl, 1 dwg, 3 ex
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